Radioprotection and anti-cancer effect of Hatakeshimeji (Lyophyllum decastes)
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چکیده
Our preceding studies have demonstrated that Hatakeshimeji (Lyophyllum decastes) extracts have some radiation-protection and anti-tumor effects, and, as for the mechanism of the action, the enhancement of immuno activity and the action of anti-oxidation have been elucidated. In this study, we examined anti-tumor effects, the protection of immuno disturbance and the anti-oxidation action, against radiation in Hatakeshimeji. After an intraabdominal inoculation of approximately 2 x 10 6 Sarcoma 180, ICR mice were given an endoceliac dosage 200 mg/kg of Hatakeshimeji every other day for two weeks. Two Gy of radiation was given three times and the numbers of leukocytes and lymphocyte were counted. We also measured body weight and tumor size two weeks after seeding the cancer cells. Anti-oxidation action was measured using the AAPH(2,2-azobis (2-amidinopropane) dihydrochloride)method. Comparing with that the group inoculated only with cancer cells increased the tumor size with time, some decrease in tumor size was clearly demonstrated in the group of radiation exposure 17
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تاریخ انتشار 2006